The venue in Murcia, south-east Spain, was the overwhelming choice of the readers of leading UK magazine Today's Golfer, receiving nearly 50% of votes cast.
La Manga includes three 18-hole championship courses and an array of other sports and leisure amenities.
The resort increased its total number of golf rounds played by 20% in 2013.
La Manga Club will open a new Leadbetter Academy, the only such facility on mainland Spain later this month.
Amateur Seniors Championship in February, and the first Manga Club International Pro-Am from March 7-11.
It has also been selected to host the 2014 Spanish International